Cipro side effects
During clinical investigations with oral and parenteral Ciprofloxacin, it has been seen that 49,038 patients received courses of the drug. Most of the adverse cipro side effects reported were described as only mild or moderate in severity, abated soon after the drug was discontinued, and required no treatment. Ciprofloxacin was discontinued because of the cipro side effecrs in 1% of orally treated patients.
The most frequently reported cipro side effects related events, from clinical trials of all formulations, all dosages, all drug-therapy durations, and for all indications of Ciprofloxacin therapy were nausea (2.5%), diarrhea (1.6%), liver function tests abnormal (1.3%), vomiting (1%), and rash (1%).
Additional medically important cipro side effects that occurred in less than 1% of Ciprofloxacin patients were headache, abdominal pain/discomfort, foot pain, pain, pain in extremities, injection site reaction on the body as a whole. Palpitation, atrial flutter, ventricular ectopy, syncope, hypertension, cardiopulmonary arrest, angina pectoris, cerebral thrombosis, phlebitis, migraine, myocardial infarction, hypotension in the cardiovascular system have been reported as cipro side effects. Gastrointestinally, cipro side effects may be seen as painful oral mucosa, oral candidiasis, dysphagia, intestinal perforation, gastrointestinal bleeding, cholestatic jaundice, hepatitis. Arthralgia or back pain, joint stiffness, achiness, neck or chest pain, flare up of gout may be the musuloskeletal cipro side effects. Dyspnea, laryngeal or pulmonary epistaxis, edema, hiccough, hemoptysis, bronchospasm, pulmonary embolism are the cipro side effects often seen in the respiratory system. Skin or hypersensisitivity as cipro side effects are seen as allergic reaction, pruritus, urticaria, photosensitivity/phototoxicity reaction, flushing, fever, chills, angioedema, edema of the face, neck, lips, conjunctivae or hands, cutaneous candidiasis, hyperpigmentation, erythema nodosum,and sweating. There is also blurred vision, disturbed vision, decreased visual acuity, diplopia, eye pain, tinnitus, hearing loss, bad taste, chromatopsia as cipro side effects in the special senses.
In several cases nausea, vomiting, tremor, irritability, or palpitation were decided by investigators to be related to elevated serum levels of theophylline possibly as cipro side effects because of the interaction of Ciprofloxacin.
The following adverse cipro side effects have been reported from worldwide marketing experience with fluoroquinolones, including Ciprofloxacin. Because these events are reported from a population of uncertain size so it is not always possible to reliably estimate their frequency or establish a causal relationship to the drug exposure. Decisions to include these events in labeling are typically based on one or more of the following factors: (1) seriousness of the event, (2) frequency of the reporting, or (3) strength of causal connection to the drug.
